Beyond the helix
نویسندگان
چکیده
منابع مشابه
Seeing beyond the double helix.
Epigenetics, or heritable changes not encoded in the DNA sequence, is a phenomenon important for an overall increase in the complexity of the genome without changes in gene sequence. Our complete genome is contained in each of our cells. Corneal cells are different than nerve cells due to a usage pattern of the genome that is maintained in a cellular memory of active or repressed genes. These “...
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Considerable advances in automated DNA sequencing and bioinformatics have made the sequencing of entire microbial genomes a reality (see fig 1). Researchers have been quick to recognise the scientific value of microbial sequence data, and there is now a frantic rush to sequence a wide range of important micro-organisms. The continuing release of data from these projects, combined with advances ...
متن کاملThe many faces of the helix - turn - helix domain : Transcription regulation and beyond q
The helix-turn-helix (HTH) domain is a common denominator in basal and specific transcription factors from the three superkingdoms of life. At its core, the domain comprises of an open tri-helical bundle, which typically binds DNA with the 3rd helix. Drawing on the wealth of data that has accumulated over two decades since the discovery of the domain, we present an overview of the natural histo...
متن کاملThe many faces of the helix-turn-helix domain: transcription regulation and beyond.
The helix-turn-helix (HTH) domain is a common denominator in basal and specific transcription factors from the three super-kingdoms of life. At its core, the domain comprises of an open tri-helical bundle, which typically binds DNA with the 3rd helix. Drawing on the wealth of data that has accumulated over two decades since the discovery of the domain, we present an overview of the natural hist...
متن کاملBeyond the double helix: writing and reading the histone code.
Chromatin is the physiological carrier of not only genetic information, encoded in the DNA, but also of epigenetic information including DNA methylation and histone modifications. As such histone modifications are involved in many aspects of nuclear processes including gene regulation and chromosome segregation. Recently, a 'histone code' hypothesis was put forward to explain how patterns of hi...
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ژورنال
عنوان ژورنال: Nature
سال: 2003
ISSN: 0028-0836,1476-4687
DOI: 10.1038/nj6934-927a